...you're in the middle of it
We are seeking a highly motivated PhD student to join the Translational Pediatric Oncology Research Group of Prof. Dr. Christian Braun at the Department of Pediatrics (Director: Prof. Jan-Henning Klusmann), University Hospital Frankfurt.
Our group investigates how dysregulated gene-expression programs contribute to the development and progression of pediatric cancers, with the overarching goal of identifying new therapeutic vulnerabilities. We combine advanced CRISPR-based screening approaches with transcriptomic and proteomic profiling and employ patient-derived cancer models to uncover the molecular mechanisms that drive high-risk tumors.
The successful candidate will become part of an interdisciplinary and collaborative team committed to translating molecular insights into new precision-oncology strategies for children with cancer.
The project offers substantial freedom to develop your own scientific ideas, access to advanced technologies and patient-derived cancer models, and the opportunity to contribute to research with real impact.
Your Role:
- Design and perform CRISPR-based genetic perturbation screens in patient-derived and engineered cancer models
- Analyze and interpret epigenetic, transcriptomic, and proteomic datasets using state-of-the-art statistical and computational approaches
- Functionally validate candidate genes, pathways, and molecular mechanisms in cellular model systems
- Contribute to the development and preclinical evaluation of targeted therapeutic strategies for high-risk pediatric tumors
- Present results within the research group and at scientific meetings, and contribute to publications
- Collaborate closely with clinicians, molecular biologists, and computational scientists within an interdisciplinary environment
