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The Institute of Clinical Pharmacology at Goethe University Frankfurt is seeking a PhD Candidate / Doctoral Researcher to join the research group of Dr. Hahnefeld. The successful candidate will contribute to an interdisciplinary research project in cooperation with the Fraunhofer ITMP Frankfurt at the interface of analytical chemistry, lipid biology and inflammation research.
The project investigates how lipid metabolism and lipid-mediated signaling are regulated in inflammatory settings. The work combines cell-based experiments with mass spectrometry-based lipidomics, fatty acid analysis and targeted lipid mediator measurements. A particular focus will be placed on the development, optimization and application of robust analytical and computational workflows for the analysis of complex biological datasets. The research group uses high-resolution mass spectrometry and reproducible bioinformatic approaches to investigate lipid-mediated mechanisms in inflammatory and metabolic diseases. The position offers the opportunity to work in a collaborative research environment with interdisciplinary partners in lipid biology, immunology, imaging and proteomics.
The position is limited up to three years.
Your Role:
- Plan, conduct and document experiments in cellular models of inflammation and metabolic perturbation.
- Prepare biological samples and perform LC-HRMS-based lipidomics and metabolomics measurements and further develop associated analytical workflows.
- Perform GC-HRMS-based analysis of fatty acids
- Conduct LC-MS/MS measurements of lipid mediators using established methods.
- Perform comprehensive quality control, raw-data validation, data annotation and statistical analysis of complex mass spectrometry datasets.
- Develop and apply reproducible workflows for data processing, visualization and interpretation using R and/or Python.
- Contribute to the integration and interpretation of lipidomics data with complementary datasets generated by collaborating groups, including imaging- and proteomics-based data.
- Validate selected findings in close collaboration with project partners.
- Present research results in scientific publications, project meetings and at national and international conferences.
